Graphene oxide and electroactive reduced graphene oxide-based composite fibrous scaffolds for engineering excitable nerve tissue

نویسندگان

چکیده

This study systematically investigates the role of graphene oxide (GO) and reduced GO (rGO)/silk-based composite micro/nano-fibrous scaffolds in regulating neuronal cell behavior vitro, given limited comparative studies on effects family materials nerve regeneration. Fibrous can mimic architecture native extracellular matrix are potential candidates for tissue engineering peripheral nerves. Silk/GO were electrospun with loadings 1 to 10 wt.%, optionally post-reduced situ explore a electrically conductive non-woven silk/rGO scaffolds. Conductivities up 4 × 10?5 S cm?1 recorded dry state, which increased 3 10?4 after hydration. Neuronoma NG108-15 cells adhered viable all substrates. Enhanced metabolic activity proliferation observed GO-containing scaffolds, these responses further promoted electroactive silk/rGO. Neurite extensions 100 ?m achieved by day 5, maximum outgrowth ~250 some These fibrous exhibit enhance response could be versatile supportive substrates neural applications.

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ژورنال

عنوان ژورنال: Materials Science and Engineering: C

سال: 2021

ISSN: ['1873-0191', '0928-4931']

DOI: https://doi.org/10.1016/j.msec.2020.111632